We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Action of carvacrol in Salmonella Typhimurium biofilm: A proteomic study.
- Authors
Coelho Trevisan, Daliah Alves; Zanetti Campanerut-Sá, Paula Aline; da Silva, Alex Fiori; Pereira Batista, Andreia Farias; Vicente Seixas, Flavio Augusto; Peralta, Rosane Marina; de Sá-Nakanishi, Anacharis Babeto; de Abreu Filho, Benício Alves; Junior, Miguel Machinski; Graton Mikcha, Jane Martha
- Abstract
Carvacrol presents action in Salmonella Typhimurium biofilms, however the antibiofilm mechanism of this compound has not been fully established yet. In the present study, the aim was to evaluate protein profile changes in S. Typhimurium biofilm treated with carvacrol. Proteomic analysis of treated versus untreated biofilm showed several changes in proteins involved with S. Typhimurium biofilm and antioxidant activity. The proteins DsbA (thiol: disulfide interchange protein DsbA), LuxS (S-ribosylhomocysteine lyase), DksA (RNA polymerase binding transcription factor DksA), and SODs (superoxide dismutases) A, B and C had their synthesis decreased after treatment with carvacrol. These proteins play a key role in S. Typhimurium biofilm formation, demonstrating the dynamic antibiofilm action of carvacrol. The differentially expressed proteins identified provide possible action targets for future studies in order to gain more insight into the mechanism of action of carvacrol on S. Typhimurium biofilm.
- Subjects
CARVACROL; SALMONELLA typhimurium; PROTEOMICS; BIOFILMS; ANTIOXIDANTS
- Publication
Journal of Applied Biomedicine, 2020, Vol 18, Issue 4, p106
- ISSN
1214-021X
- Publication type
Article
- DOI
10.32725/jab.2020.014