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- Title
Comparison of low molecular weight hydroxyethyl starch and human albumin as priming solutions in children undergoing cardiac surgery.
- Authors
Miao, Na; Yang, Jing; Du, Zhongtao; Liu, Wei; Ni, Hong; Xing, Jialin; Yang, Xiaofang; Xu, Bo; Hou, Xiaotong
- Abstract
Human albumin is the conventional cardiopulmonary bypass circuit primer. However, it has high manufacturing costs. Crystalloid and colloid solutions have been developed as alternatives, including a new generation of non-ionic hydroxyethyl starch (HES). The efficacy of hydroxyethyl starch with a 130 molecular weight and substitution degree of 0.4 (hydroxyethyl starch 130/0.4) was compared with human albumin for use in cardiopulmonary bypass surgery in American Society of Anesthesiologists’ grade I-II pediatric congenital heart disease patients. Efficacy was evaluated by comparing perioperative hemodynamic parameters, including plasma colloid osmotic pressure, renal function, blood loss, allogeneic blood volumes and plasma volume substitution. The hydroxyethyl starch group exhibited significantly higher preoperative colloid osmotic pressure (p<0.01) and significantly lower operative renal function and postoperative allogeneic blood volumes than the human albumin group. No significant differences were observed in serum creatinine, glucose, hematocrit or lactic acid levels (p>0.05). Our results indicate that hydroxyethyl starch may be a viable alternative to human albumin in pediatric patients undergoing relatively simple cardiopulmonary bypass surgeries.
- Subjects
CHINA; MYOCARDIAL revascularization; TRANSLUMINAL angioplasty; COLLOIDS; ACADEMIC medical centers; ANALYSIS of variance; BLOOD testing; FISHER exact test; HEALTH outcome assessment; RESEARCH funding; T-test (Statistics); TREATMENT effectiveness; DATA analysis software; DESCRIPTIVE statistics; OSMOTIC pressure; CHILDREN; THERAPEUTICS
- Publication
Perfusion, 2014, Vol 29, Issue 5, p462
- ISSN
0267-6591
- Publication type
Article
- DOI
10.1177/0267659114528267