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- Title
Immunohistochemistry of two glycolipid tissue antigens in human gastric carcinoma.
- Authors
Wang, Shih-Ming; Huang, Thomas W.; Hakomori, S.; Wang, S M; Huang, T W
- Abstract
Immunohistochemical studies of two glycolipid tissue antigens were carried out to ascertain their distribution in normal as well as cancerous gastric mucosa. A trihexose ceramide (Kiyo antigen), a precursor of ABH blood group substances, is present in epithelial cell membrane and mucin of 90% (45 of 50) of noncancerous gastric mucosa. The distribution is similar to blood group substance; 10.7% (3 of 28) of gastric carcinoma that arose in Kiyo-positive gastric mucosa exhibited complete loss of the antigen, while carcinomas from Kiyo-negative gastric mucosa remained Kiyo negative. A fucopentaose ceramide (Lex), however, is absent from noncancerous gastric mucosa but present in varying quantity in 92.9% (52 of 56) of gastric carcinomas. The emergence of Lex as a tumor cell marker in the great majority of gastric carcinomas indicates its potential application in the diagnosis and assessment of tumor loads in gastric carcinoma patients.
- Publication
Cancer (0008543X), 1983, Vol 52, Issue 11, p2072
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19831201)52:11<2072::AID-CNCR2820521117>3.0.CO;2-X