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- Title
Low-dose preoperative irradiation, surgery, and elective postoperative radiation therapy for resectable rectum and rectosigmoid carcinoma.
- Authors
Gunderson, Leonard L.; Dosoretz, Daniel E.; Hedberg, Steven E.; Blitzer, Peter H.; Rodkey, Grant; Hoskins, Bruce; Shipley, William U.; Cohen, Alfred C.; Gunderson, L L; Dosoretz, D E; Hedberg, S E; Blitzer, P H; Rodkey, G; Hoskins, B; Shipley, W U; Cohen, A C
- Abstract
A regimen of low-dose preoperative radiation therapy (RT), surgery, and elective postoperative RT for resectable carcinomas of the rectum and rectosigmoid is presented. Initial results in a group of 36 patients is discussed. In four patients clinically silent metastatic disease was discovered. Of 16 patients without indications for postoperative RT, only one died with disease. Indications for postoperative irradiation were found in 15 patients and four relapses (26%) subsequently occurred. Since the surgicopathologic stage of the tumor is the best prognostic predictor for rectal cancer, this regimen allows for the delivery of high-dose adjuvant irradiation only to those at high risk of local recurrence. Thus, this combination selects patients likely to benefit from postoperative RT while preserving the advantages of preoperative RT.
- Publication
Cancer (0008543X), 1983, Vol 52, Issue 3, p446
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19830801)52:3<446::AID-CNCR2820520311>3.0.CO;2-H