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- Title
Hepatic failure secondary to indicine N-oxide toxicity. A Pediatric Oncology Group Study.
- Authors
Cook, Bruce A.; Sinnhuber, John R.; Thomas, Paul J.; Olson, Thomas A.; Silverman, Toby A.; Jones, Robert; Whitehead, V. Michael; Ruymann, Frederick B.; Cook, B A; Sinnhuber, J R; Thomas, P J; Olson, T A; Silverman, T A; Jones, R; Whitehead, V M; Ruymann, F B
- Abstract
Indicine N-oxide, a pyrrolizidine alkaloid, was given to a five-year-old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N-oxide toxicity.
- Publication
Cancer (0008543X), 1983, Vol 52, Issue 1, p61
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19830701)52:1<61::AID-CNCR2820520112>3.0.CO;2-W