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- Title
Prolonged complete remission following high dose chemotherapy of Burkitt's lymphoma in relapse.
- Authors
Appelbaum, Frederick R.; Deisseroth, Albert B.; Graw, Robert G.; Herzig, Geoffrey P.; Levine, Arthur S.; Magrath, Ian T.; Pizzo, Phillip A.; Poplack, David G.; Ziegler, John L.; Appelbaum, F R; Deisseroth, A B; Graw, R G Jr; Herzig, G P; Levine, A S; Magrath, I T; Pizzo, P A; Poplack, D G; Ziegler, J L
- Abstract
Fourteen patients with American Burkitt's lymphoma resistant to conventional chemotherapy were treated with high-dose combination chemotherapy and intensive supportive care. Four patients died shortly after chemotherapy, 3 of an acute carditis. All ten remaining patients demonstrated tumor regression and 3 remain in prolonged complete unmaintained remission 29+, 19+, and 9+ months after treatment. These findings demonstrate that high-dose chemotherapy will benefit some patients with Burkitt's lymphoma unresponsive to conventional chemotherapy, but the medullary and extramedullary toxicity of this treatment strategy remains a formidable obstacle.
- Publication
Cancer (0008543X), 1978, Vol 41, Issue 3, p1059
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197803)41:3<1059::AID-CNCR2820410339>3.0.CO;2-N