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- Title
Small cell cancer of the uterine cervix.
- Authors
van Nagell, J. R.; Donaldson, E. S.; Wood, E. G.; Maruyama, Y.; Utley, J.; Van Nagell, J R Jr
- Abstract
Forty-one patients with small cell carcinoma of the uterine cervix were evaluated and treated at the University of Kentucky Medical Center from 1962 to 1974. Eighteen patients (44%) developed widespread metastases and died of recurrent cancer within 2 years of therapy. Common sites of metastases included the lung, liver, and bone. There was a significantly lower incidence of lymphoplasmacytic infiltration in small cell cancers than the keratinizing or nonkeratinizing squanmous cell carcinomas of the cervix. In addition, there was a significant increase in the number of unstimulated regional lymph nodes in patients with small cell cancer when compared with the lymph nodes of patients with the other cell types of cervical cancer. These data suggest that small cell cancer of the cervix is a highly aggressive tumor similar to small cell carcinoma of the lung and behaves quite differently from other types of squamous cell carcinoma of the cervix. Radiation therapy was superior to radical surgery in eradicating pelvic disease, but prospective studies need to be undertaken to determine the effect of adjunctive chemotherapy in patients with this rare tumor.
- Subjects
CANCER treatment; CANCER; HYSTERECTOMY; LYMPH nodes; RADIATION doses; CERVIX uteri tumors
- Publication
Cancer (0008543X), 1977, Vol 40, Issue 5, p2243
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(197711)40:5<2243::AID-CNCR2820400534>3.0.CO;2-H