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- Title
Co-stimulation of human breast cancer cells with transforming growth factor-β and tenascin-C enhances matrix metalloproteinase-9 expression and cancer cell invasion.
- Authors
Ilunga, Kalembeyi; Nishiura, Rika; Inada, Hiroyasu; El-Karef, Amro; Imanaka-Yoshida, Kyoko; Sakakura, Teruyo; Yoshida, Toshimichi
- Abstract
Transforming growth factor-n (TGF-Β), tenascin-C (TN-C) and matrix metalloproteinases (MMPs) have been demonstrated independently to be associated with disease progression and poor prognosis in patients with breast cancer. The present study explored effects of TGF-Β and TN-C on MMP-9 expression and cancer invasion. An experimental study was designed to analyse MDA-MB-23 I breast cancer cells, known for their high invasiveness, after stimulation with TGF-Β1 and/or TN-C. TGF-Β1 stimulated TN-C expression in the cells. Co-stimulation of MDA-MB-23 I cells with TN-C and TGF-13 increased MMP-9 expression at both the gene (28-fold) and the protein levels. The in vitro invasion also increased (4-fold). GM600I inhibited the invasion induced by the co-stimulation. The combined effect of TN-C and TGF-13 resulted in enhanced MMP-9 expression and cancer invasion in vitro.
- Subjects
TRANSFORMING growth factors; GROWTH factors; TRANSFORMING growth factors-beta; BREAST cancer; CANCER cells; CELLULAR pathology
- Publication
International Journal of Experimental Pathology, 2004, Vol 85, Issue 6, p373
- ISSN
0959-9673
- Publication type
Article
- DOI
10.1111/j.0959-9673.2004.00406.x