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- Title
Interleukin-2 and the IL-2 Receptor: New Insight Into Structure and Function.
- Authors
Kuziel, William A.; Greene, Warner C.
- Abstract
Interleukin-2 (IL-2) was originally identified in 1976 as a growth factor for T lymphocytes. Since that time it has become an important mediator of immune function through its effects on the growth, development, and activity of T and B lymphocytes, natural killer cells, and lymphokine-activated killer cells. Only cells that bear a specific receptor for IL-2 respond to its immunoregulatory effects. Of all the lympho-kine-receptor systems in immunology, perhaps most is known about the structure, function, and binding properties of IL-2 and its cognate receptor. There are two distinct, membrane-associated IL-2 binding components in the high-affinity IL-2 receptor: an α subunit and a β subunit, which associate in a non-covalent manner. Each of these polypeptides can occur on the cell surface in the absence of the other and bind IL-2, although with only low or intermediate affinity relative to the high-affinity receptor complex. The primary structure of each chain has now been deduced from full-length cDNA. The rapid rate of association between IL-2 and the IL-2Rα subunit is important in the formation of high-affinity binding sites, and the inducibility of the a gene contributes to the highly regulated and transient display of high-affinity IL-2R. The IL-2Rβ chain controls the slow dissociation rate of IL-2 from the high-affinity receptor. Also, IL-2Rβ appears centrally involved in internalization of IL-2 and signal transduction, functions mediated presumably through its long intracytoplasmic domain. However, the actual mechanism of signal transduction in the IL-2/IL-2R system remains undefined. IL-2Rβ is a member of a novel family of cytokine-receptor proteins that includes receptors for IL-4, IL-6, and erythropoietin.
- Subjects
INTERLEUKIN-2; CELL receptors; IMMUNOMODULATORS; IMMUNOREGULATION; IMMUNOLOGY; INTERLEUKINS
- Publication
Journal of Investigative Dermatology, 1990, Vol 94, p27s
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12875017