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- Title
Leukotrienes C<sub>4</sub> and D<sub>4</sub> As Potent Mitogens for Cultured Human Neonatal Melanocytes.
- Authors
Morelli, Joseph G.; Yohn, Joseph J.; Lyons, M. Bradley; Murphy, Robert C.; Norris, David A.
- Abstract
Arachidonic acid and its metabolites (eicosanoids) are membrane-derived inflammatory mediators with a diverse set of biologic properties affecting numerous cells and organ systems, including the skin. They have been implicated in the pathogenesis of inflammatory skin disease and post-inflammatory hyperpigmentation. We have studied the ability of arachidonic acid, prostaglandin D2, Prostaglandin E2, leukotriene B4, leukotriene D4, and leukotriene E4 to enhance the growth of cultured human melanocytes. Of these compounds, only leukotriene C4 were capable of stimulating melanocyte proliferation. In addition, cultured melanocytes metabolized leukotriene C4 to leukotriene E4 with greater than 60% conversion in less than three hours. Melanocytes grown on suboptimal media (doubling time 12-20 days) respond in a dose-dependent fashion to leukotriene C4, with a significant difference from control noted at 28 days with a concentration of LTC4 of 30 nM and a doubling time of 5-8 days. We feel that leukotriene C4 and D4 could play an important role in post-inflammatory melanocyte hyperplasia.
- Subjects
ARACHIDONIC acid; LEUKOTRIENES; EICOSANOIDS; MELANOCYTES; HYPERPLASIA; MITOGENS; SKIN diseases; PROSTAGLANDINS
- Publication
Journal of Investigative Dermatology, 1989, Vol 93, Issue 6, p719
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12284392