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- Title
Associated factors of umbilical cord blood collection quality.
- Authors
Faivre, Lionel; Couzin, Chloé; Boucher, Hélène; Domet, Thomas; Desproges, André; Sibony, Olivier; Bechard, Marina; Vanneaux, Valérie; Larghero, Jérôme; Cras, Audrey
- Abstract
After 30 years of hematopoietic stem cell use for various indications, umbilical cord blood is considered as an established source of cells with marrow and postmobilization peripheral blood. The limited number of cells still remains a problematic element restricting their use, especially in adults who require to be grafted with a higher cell number. Improving the quality of harvested cord blood, at least in terms of volume and amount of cells, is essential to decrease the number of discarded units. In this review, we examine several variables related to parturient, pregnancy, labor, delivery, collection, the newborn, umbilical cord, and placenta. We aim to understand the biologic mechanisms that can impact cord blood quality. This knowledge will ultimately allow targeting donors, which could provide a rich graft and improve the efficiency of the collection.
- Subjects
CORD blood transplantation; BLOOD transfusion reaction; BLOOD group incompatibility; BLOOD transfusion; BLOOD testing; HISTOCOMPATIBILITY; SAFETY; CORD blood; BLOOD donors; BONE marrow transplantation; HEMATOPOIETIC stem cell transplantation; QUALITY assurance; PHENOMENOLOGICAL biology; PHYSIOLOGY
- Publication
Transfusion, 2018, Vol 58, Issue 2, p520
- ISSN
0041-1132
- Publication type
journal article
- DOI
10.1111/trf.14447