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- Title
Effect of preoperative intravenous pantoprazole in elective-surgery patients: a pilot study.
- Authors
Pisegna, Joseph R; Karlstadt, Robyn G; Norton, Jeffrey A; Fogel, Ronald; Oh, David S; Jay Graepel, G; Dorr, Mary Beth
- Abstract
<bold>Background: </bold>This study evaluated the effects of intravenous pantoprazole on gastric volume and acid output in elective-surgical patients.<bold>Methods: </bold>This is a multicenter, randomized, pilot study of adult patients receiving intravenous pantoprazole: 40 mg every 24 h, 40 mg every 12 h (q12h) or 80 mg q12h. The first dose was administered 1 h before general anesthesia for surgery. All gastric fluid was aspirated through a nasogastric tube 1 h before dosing and through the postoperative period. Aspirate volume was recorded; pH and H(+) concentrations were measured.<bold>Result: </bold>Twenty-six patients were enrolled and 21 were evaluable. Pantoprazole was well tolerated. All regimens decreased gastric acid output and volume, and increased pH within 1 h of dosing. Effects were sustained for up to 12 h following single-dose administration.<bold>Conclusions: </bold>Intravenous pantoprazole administered prior to anesthesia induction may be efficacious for the reduction of gastric volume and acid output, and for pulmonary aspiration prophylaxis in surgical patients.
- Subjects
UNITED States; ABDOMINAL surgery; RESPIRATORY aspiration; COMPARATIVE studies; DRUG administration; GASTRIC acid; GASTRIC mucosa; HYDROGEN-ion concentration; INTRAVENOUS therapy; RESEARCH methodology; MEDICAL cooperation; PREANESTHETIC medication; RESEARCH; GASTRIC intubation; SULFUR compounds; ELECTIVE surgery; TIME; PROTON pump inhibitors; PILOT projects; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; MEDICAL suction; GASTRIC acidity determination; PREVENTION
- Publication
Digestive Diseases & Sciences, 2009, Vol 54, Issue 5, p1041
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-008-0445-1