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- Title
Protective Effect of a Novel Rice Extract Against Ethanol-Induced Gastric Mucosal Injury in Rat.
- Authors
Tamotsu Matsuhashi; Michiro Otaka; Masaru Odashima; Mario Jin; Koga Komatsu; Isao Wada; Youhei Horikawa; Reina Ohba; Jinko Oyake; Natsumi Hatakeyama; Sumio Watanabe
- Abstract
Abstract??The aim of this study was to investigate the protective action of rice extract on ethanol-induced mucosal damage in vivo and wound healing of epithelial cells in vitro. Also, the effect of rice extract on gastric mucosal prostaglandin E2level, HSP72 expression, gastric acid secretion, and contribution of vanilloid receptor-mediated action was studied. In addition, using cultured gastric mucosal cells (RGM-1), the effect of rice extract on cytoprotection and wound healing of epithelial cells was evaluated. Rice extract significantly reduced gastric mucosal damage produced by ethanol in vivo, and heat treatment (80?C, 3?min) of this agent did not alter its protective effect. Rice extract also protected RGM-1 from ethanol-induced damage in a dose-dependent manner. Rice extract accelerated wound healing of gastric epithelial cells. Our results demonstrate that rice extract could be an alternative ulcer treatment that provides cytoprotection and enhancement of wound healing not dependent on acid secretion, prostaglandin E2level, HSP72 expression, or vanilloid receptors.
- Subjects
EPITHELIAL cells; EPITHELIUM; WOUND healing; GASTRIC acid
- Publication
Digestive Diseases & Sciences, 2007, Vol 52, Issue 2, p434
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-006-9571-9