We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis.
- Authors
Li, Zhan-Chun; Cheng, Guang-Qi; Hu, Kong-Zu; Li, Mao-Qiang; Zang, Wei-Ping; Dong, Yu-Qi; Wang, Wei-Li; Liu, Zu-De
- Abstract
<bold>Purpose: </bold>This study measured high-mobility group box 1 (HMGB-1) levels in serum and synovial fluid (SF) in patients with primary knee osteoarthritis (OA) and correlated these levels with radiographic disease severity.<bold>Methods: </bold>Seventy-eight OA patients and 30 controls were enrolled in this study. All OA patients were scored according to the Kellgren-Lawrence (KL) grading system. HMGB-1 levels were measured by enzyme-linked immunosorbent assay (ELISA).<bold>Results: </bold>SF HMGB-1 levels were significantly higher in knee OA patients, compared with controls (P < 0.01). Moreover, SF HMGB-1 levels were positively associated with KL scores (P < 0.01). Multinomial logistic regression demonstrated that the SF HMGB-1 level was an independent factor for radiographic severity of OA (P=0.002); however, serum HMGB-1 levels did not differ significantly between OA patients and controls and did not correlate with KL scores (P > 0.05).<bold>Conclusion: </bold>These results demonstrate that HMGB-1 levels in SF of knee OA patients are independently associated with radiographic disease severity.
- Publication
Clinical & Investigative Medicine, 2011, Vol 34, Issue 5, pE298
- ISSN
0147-958X
- Publication type
journal article