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- Title
DNMT3A mutations in acute myeloid leukemia.
- Authors
Shah, Mrinal Y.; Licht, Jonathan D.
- Abstract
New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.
- Subjects
ACUTE myeloid leukemia; METHYLTRANSFERASES; ANTIBODY diversity; HEMATOPOIESIS; GENE expression; HUMAN genome; DNA; GENETICS
- Publication
Nature Genetics, 2011, Vol 43, Issue 4, p289
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng0411-289