We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
- Authors
Stephens, Philip; Edkins, Sarah; Davies, Helen; Greenman, Chris; Cox, Charles; Hunter, Chris; Bignell, Graham; Teague, Jon; Smith, Raffaella; Stevens, Claire; O'Meara, Sarah; Parker, Adrian; Tarpey, Patrick; Avis, Tim; Barthorpe, Andy; Brackenbury, Lisa; Buck, Gemma; Butler, Adam; Clements, Jody; Cole, Jennifer
- Abstract
We examined the coding sequence of 518 protein kinases,~1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
- Subjects
PROTEIN kinases; BREAST cancer; PHOSPHOTRANSFERASES; DNA; GENES; TUMORS
- Publication
Nature Genetics, 2005, Vol 37, Issue 6, p590
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1571