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- Title
Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population.
- Authors
Mira, Marcelo T.; Alcais, Alexandre; Van Thuc, Nguyen; Thai, Vu Hong; Huong, Nguyen Thu; Ba, Nguyen Ngoc; Verner, Andrei; Hudson, Thomas J.; Abel, Laurent; Schurr, Erwin
- Abstract
Leprosy, a chronic infectious disease caused by Mycobacterium leprae, affects an estimated 700,000 persons each year. Clinically, leprosy can be categorized as paucibacillary or multibacillary disease. These clinical forms develop in persons that are intrinsically susceptible to leprosy per se, that is, leprosy independent of its specific clinical manifestation. We report here on a genome-wide search for loci controlling susceptibility to leprosy per se in a panel of 86 families including 205 siblings affected with leprosy from Southern Vietnam. Using model-free linkage analysis, we found significant evidence for a susceptibility gene on chromosome region 6q25 (maximum likelihood binomial (MLB) Iod score 4.31; P = 5 × 10[sup -6]). We confirmed this by family-based association analysis in an independent panel of 208 Vietnamese leprosy simplex families. Of seven microsatellite markers underlying the linkage peak, alleles of two markers (D651035 and D65305) showed strong evidence for association with leprosy (P = 6.7 × 10[sup -4] and P = 5.9 × 10[sup -5], respectively).
- Subjects
VIETNAM; HANSEN'S disease; CHROMOSOME abnormalities; GENETICS
- Publication
Nature Genetics, 2003, Vol 33, Issue 3, p412
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1096