We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Follicular Variant of Papillary Thyroid Carcinoma: Increasing Rate of Diagnosis and Clinical Behavior.
- Authors
Hunt, Jason P.; Buchmann, Luke O.; Jarboe, Elke A.; Abraham, Dev
- Abstract
Objectives: Follicular variant of papillary thyroid carcinoma (FVPTC) has a similar prognosis to conventional papillary thyroid carcinoma (CPTC). We present the largest single institution clinical experience of FVPTC with comparison to its conventional counterpart to describe changes in rate of diagnosis and clinical features. Study Design: Retrospective chart review at an academic tertiary care hospital. Methods: A retrospective chart review from July 2004 through June 2010 of all newly diagnosed papillary thyroid carcinomas evaluated for surgery in the head and neck clinic. FVPTC cases were compared to CPTC cases in terms of demographics, primary tumor characteristics, lymph node and distant metastases. Results: There were 233 diagnoses of follicular variants or conventional PTCs that underwent surgery over six years. There were 107 newly diagnosed FVPTCs and 126 CPTCs. The rate of diagnosis of FVPTC increased from 1 case per month early in the study to 2.35 cases over the last two years of the study. The two groups were similar in gender distribution and multifocality. However, FVPTC tumors were smaller (1.20 vs 1.70 cm) (p=0.01) with fewer cases of extrathyroid extension (7% vs 33%) (p<0.01). They were diagnosed in older individuals (46 vs 41.5 years) (p=0.018) and had fewer lymph node metastases (21% vs 55%) (p<0.01). Conclusions: The rate of diagnosis of FVPTC is increasing. It appears to have a favorable prognosis as CPTC, but may have fewer lymph node metastases and less aggressive clinical characteristics. Followup studies are needed to determine the reason for increase in incidence and possible differences in treatments.
- Subjects
THYROID cancer; LYMPH nodes; SURGERY; TUMORS; METASTASIS
- Publication
Laryngoscope, 2011, Vol 121, Issue S4, pS124
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.22001