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- Title
A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.
- Authors
Noziéres, Cécile; Walter, Thomas; Joly, Marie-Odile; Giraud, Sophie; Scoazec, Jean-Yves; Borson-Chazot, Françoise; Simon, Chantal; Riou, Jean-Paul; Lombard-Bohas, Catherine
- Abstract
Ten percent of paragangliomas are malignant and one-third occurs in a genetic background. We report a case of succinate dehydrogenase subunit B (SDHB)-related malignant paraganglioma with dramatic response to temozolomide and capecitabine regimen (decrease in tumor size of 70% with RECIST criteria). Tumor cells harbored a new mutation in SDHB gene and showed aberrant hypermethylation of O6-methylguanine-DNA-methyltransferase promoter. Our report suggests the importance of molecular predictive factors of response for the selection of chemotherapeutic as well as targeted agents. This observation points to a possible genotype response to treatment relationships, which could help to design tailor-made treatments in the future.
- Subjects
SUCCINATE dehydrogenase; PARAGANGLIOMA; CANCER cells; GENETIC mutation; O6-Methylguanine-DNA Methyltransferase; DNA methylation; DNA methyltransferases
- Publication
European Journal of Endocrinology, 2012, Vol 166, Issue 6, p1107
- ISSN
0804-4643
- Publication type
Article
- DOI
10.1530/EJE-11-1098