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- Title
DIABLO Promotes Apoptosis by Removing MIHA/XIAP from Processed Caspase 9.
- Authors
Ekert, Paul G.; Silke, John; Hawkins, Christine J.; Verhagen, Anne M.; Vaux, David L.
- Abstract
Shows that after ultraviolet radiation, MIHA, an inhibitor of apoptosis protein (IAP), prevented apoptosis by inhibiting caspase 9 and caspase 3 activation. Effect of MIHA on serum withdrawal-induced apoptosis; MIHA binding to endogenous, processed caspase 3; MIHA function downstream of mitochondrial cytochrome c and release of the mammalian protein, DIABLO.
- Subjects
APOPTOSIS prevention; PROTEINS; PHYSIOLOGICAL effects of ultraviolet radiation; CHEMICAL inhibitors
- Publication
Journal of Cell Biology, 2001, Vol 152, Issue 3, p483
- ISSN
0021-9525
- Publication type
Article
- DOI
10.1083/jcb.152.3.483