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- Title
Computational optical biopsy.
- Authors
Li, Yi; Jiang, Ming; Wang, Ge
- Abstract
Optical molecular imaging is based on fluorescence or bioluminescence, and hindered by photon scattering in the tissue, especially in patient studies. Here we propose a computational optical biopsy (COB) approach to localize and quantify a light source deep inside a subject. In contrast to existing optical biopsy techniques, our scheme is to collect optical signals directly from a region of interest along one or multiple biopsy paths in a subject, and then compute features of an underlying light source distribution. In this paper, we formulate this inverse problem in the framework of diffusion approximation, demonstrate the solution uniqueness properties in two representative configurations, and obtain analytic solutions for reconstruction of both optical properties and source parameters.
- Subjects
BIOPSY; CLINICAL pathology; FLUORESCENCE; PHOTON scattering; OPERATIVE surgery
- Publication
BioMedical Engineering OnLine, 2005, Vol 4, p36
- ISSN
1475-925X
- Publication type
Article
- DOI
10.1186/1475-925X-4-36