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- Title
Peritoneal metastasis of colorectal cancer (pmCRC): identification of predictive molecular signatures by a novel preclinical platform of matching pmCRC PDX/PD3D models.
- Authors
Dahlmann, Mathias; Gambara, Guido; Brzezicha, Bernadette; Popp, Oliver; Pachmayr, Eva; Wedeken, Lena; Pflaume, Alina; Mokritzkij, Margarita; Gül-Klein, Safak; Brandl, Andreas; Schweiger-Eisbacher, Caroline; Mertins, Philipp; Hoffmann, Jens; Keilholz, Ulrich; Walther, Wolfgang; Regenbrecht, Christian; Rau, Beate; Stein, Ulrike
- Abstract
2 Multi-omics characterization of pmCRC metastases, PDX tumors and PD3D models confirms similarity of matched pmCRC models and can be used for predictive biomarker analysis. Growth and treatment response of pmCRC PD3D models and high correlation of molecular characteristics indicate high similarity of each generated pair of matched pmCRC PDX and PD3D cell culture models. A) Transcriptomic single sample enrichment analysis of signatures predicting treatment response to selected anti-cancer drugs of pmCRC metastases, PDX tumors and PD3D culture cell models. For identification of novel predictive biomarkers in pmCRC for SoC and targeted drug treatments we molecularly characterized the original patient pmCRC and corresponding PDX/PD3D models by RNAseq and patient-derived pmCRC models also by mass-spectrometry proteomics and phosphoproteomics.
- Subjects
PERITONEAL cancer; MUCINOUS adenocarcinoma; COLORECTAL cancer; METASTASIS; FOCAL adhesion kinase; ORGANIC anion transporters; DNA repair
- Publication
Molecular Cancer, 2021, Vol 20, Issue 1, p1
- ISSN
1476-4598
- Publication type
Article
- DOI
10.1186/s12943-021-01430-7