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The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets.
Published in:
Cells (2073-4409), 2024, v. 13, n. 20, p. 1685, doi. 10.3390/cells13201685
By:
- Snelders, Matthijs;
- Yildirim, Meltem;
- Danser, A. H. Jan;
- van der Pluijm, Ingrid;
- Essers, Jeroen
Publication type:
Article
Multi-Omics Profiling in Marfan Syndrome: Further Insights into the Molecular Mechanisms Involved in Aortic Disease.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 1, p. 438, doi. 10.3390/ijms23010438
By:
- Verhagen, Judith M. A.;
- Burger, Joyce;
- Bekkers, Jos A.;
- den Dekker, Alexander T.;
- von der Thüsen, Jan H.;
- Zajec, Marina;
- Brüggenwirth, Hennie T.;
- van der Sterre, Marianne L. T.;
- van den Born, Myrthe;
- Luider, Theo M.;
- van IJcken, Wilfred F. J.;
- Wessels, Marja W.;
- Essers, Jeroen;
- Roos-Hesselink, Jolien W.;
- van der Pluijm, Ingrid;
- van de Laar, Ingrid M. B. H.;
- Brosens, Erwin
Publication type:
Article
In Vivo Renin Activity Imaging in the Kidney of Progeroid Ercc1 Mutant Mice.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 22, p. 12433, doi. 10.3390/ijms222212433
By:
- van Thiel, Bibi S.;
- van der Linden, Janette;
- Ridwan, Yanto;
- Garrelds, Ingrid M.;
- Vermeij, Marcel;
- Clahsen-van Groningen, Marian C.;
- Qadri, Fatimunnisa;
- Alenina, Natalia;
- Bader, Michael;
- Roks, Anton J. M.;
- Danser, A. H. Jan;
- Essers, Jeroen;
- van der Pluijm, Ingrid
Publication type:
Article
Chronic Sildenafil Treatment Improves Vasomotor Function in a Mouse Model of Accelerated Aging.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 13, p. 4667, doi. 10.3390/ijms21134667
By:
- Golshiri, Keivan;
- Ataei Ataabadi, Ehsan;
- Brandt, Renata;
- van der Pluijm, Ingrid;
- de Vries, René;
- Danser, A. H. Jan;
- Roks, Anton
Publication type:
Article
Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell.
Published in:
Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/2308317
By:
- Ataei Ataabadi, Ehsan;
- Golshiri, Keivan;
- van der Linden, Janette;
- de Boer, Martine;
- Duncker, Dirk J.;
- Jüttner, Annika;
- de Vries, René;
- Van Veghel, Richard;
- van der Pluijm, Ingrid;
- Dutheil, Sophie;
- Chalgeri, Suman;
- Zhang, Lei;
- Lin, Amy;
- Davis, Robert E.;
- Snyder, Gretchen L.;
- Danser, A. H. Jan;
- Roks, Anton J. M.
Publication type:
Article
Extracellular Matrix Defects in Aneurysmal Fibulin-4 Mice Predispose to Lung Emphysema.
Published in:
PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0106054
By:
- Ramnath, Natasja W. M.;
- van de Luijtgaarden, Koen M.;
- van der Pluijm, Ingrid;
- van Nimwegen, Menno;
- van Heijningen, Paula M.;
- Swagemakers, Sigrid M. A.;
- van Thiel, Bibi S.;
- Ridwan, Ruziedi Y.;
- van Vliet, Nicole;
- Vermeij, Marcel;
- Hawinkels, Luuk J. A. C.;
- de Munck, Anne;
- Dzyubachyk, Oleh;
- Meijering, Erik;
- van der Spek, Peter;
- Rottier, Robbert;
- Yanagisawa, Hiromi;
- Hendriks, Rudi W.;
- Kanaar, Roland;
- Rouwet, Ellen V.
Publication type:
Article
Increased vascular smooth muscle cell senescence in aneurysmal Fibulin-4 mutant mice.
Published in:
NPJ Aging, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41514-024-00154-4
By:
- Stefens, Sanne J. M.;
- van Vliet, Nicole;
- IJpma, Arne;
- Burger, Joyce;
- Li, Yunlei;
- van Heijningen, Paula M.;
- Lindeman, Jan H. N.;
- Majoor-Krakauer, Danielle;
- Verhagen, Hence J. M.;
- Kanaar, Roland;
- Essers, Jeroen;
- van der Pluijm, Ingrid
Publication type:
Article
Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice.
Published in:
Molecular Imaging & Biology, 2024, v. 26, n. 4, p. 628, doi. 10.1007/s11307-024-01902-4
By:
- van Thiel, Bibi S.;
- de Boer, Martine;
- Ridwan, Yanto;
- de Kleijnen, Marion G. J.;
- van Vliet, Nicole;
- van der Linden, Janette;
- de Beer, Isa;
- van Heijningen, Paula M.;
- Vermeij, Wilbert P.;
- Hoeijmakers, Jan H. J.;
- Danser, A. H. Jan;
- Kanaar, Roland;
- Duncker, Dirk J.;
- van der Pluijm, Ingrid;
- Essers, Jeroen
Publication type:
Article
Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.
Published in:
Cardiovascular Research, 2018, v. 114, n. 13, p. 1776, doi. 10.1093/cvr/cvy150
By:
- van der Pluijm, Ingrid;
- Burger, Joyce;
- Heijningen, Paula M van;
- IJpma, Arne;
- Vliet, Nicole van;
- Milanese, Chiara;
- Schoonderwoerd, Kees;
- Sluiter, Willem;
- Ringuette, Lea-Jeanne;
- Dekkers, Dirk H W
Publication type:
Article
Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells.
Published in:
FEBS Journal, 2009, v. 276, n. 10, p. 2811, doi. 10.1111/j.1742-4658.2009.07004.x
By:
- Osenbroch, Pia Ø.;
- Auk-Emblem, Pia;
- Halsne, Ruth;
- Strand, Janne;
- Forstrøm, Rune J.;
- van der Pluijm, Ingrid;
- Eide, Lars
Publication type:
Article
Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz syndrome patients provides insights into genotype-phenotype relation.
Published in:
Human Molecular Genetics, 2024, v. 33, n. 12, p. 1090, doi. 10.1093/hmg/ddae044
By:
- Wagenaar, Nathalie P de;
- Bersselaar, Lisa M van den;
- Odijk, Hanny J H M;
- Stefens, Sanne J M;
- Reinhardt, Dieter P;
- Roos-Hesselink, Jolien W;
- Kanaar, Roland;
- Verhagen, Judith M A;
- Brüggenwirth, Hennie T;
- Laar, Ingrid M B H van de;
- van der Pluijm, Ingrid;
- Essers, Jeroen
Publication type:
Article
Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1.
Published in:
Human Molecular Genetics, 2021, v. 30, n. 24, p. 2286, doi. 10.1093/hmg/ddab190
By:
- Burger, Joyce;
- Bogunovic, Natalija;
- Wagenaar, Nathalie P de;
- Liu, Hui;
- Vliet, Nicole van;
- IJpma, Arne;
- Maugeri, Alessandra;
- Micha, Dimitra;
- Verhagen, Hence J M;
- Hagen, Timo L M ten;
- Majoor-Krakauer, Danielle;
- van der Pluijm, Ingrid;
- Essers, Jeroen;
- Yeung, Kak K
Publication type:
Article
Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1.
Published in:
Human Molecular Genetics, 2021, v. 30, n. 23, p. 2286, doi. 10.1093/hmg/ddab190
By:
- Burger, Joyce;
- Bogunovic, Natalija;
- Wagenaar, Nathalie P de;
- Liu, Hui;
- Vliet, Nicole van;
- IJpma, Arne;
- Maugeri, Alessandra;
- Micha, Dimitra;
- Verhagen, Hence J M;
- Hagen, Timo L M ten;
- Majoor-Krakauer, Danielle;
- van der Pluijm, Ingrid;
- Essers, Jeroen;
- Yeung, Kak K
Publication type:
Article
Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects.
Published in:
Human Molecular Genetics, 2020, v. 29, n. 9, p. 1476, doi. 10.1093/hmg/ddaa071
By:
- Boel, Annekatrien;
- Burger, Joyce;
- Vanhomwegen, Marine;
- Beyens, Aude;
- Renard, Marjolijn;
- Barnhoorn, Sander;
- Casteleyn, Christophe;
- Reinhardt, Dieter P;
- Descamps, Benedicte;
- Vanhove, Christian;
- van der Pluijm, Ingrid;
- Coucke, Paul;
- Willaert, Andy;
- Essers, Jeroen;
- Callewaert, Bert
Publication type:
Article
Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.
Published in:
PLoS ONE, 2016, v. 11, n. 3, p. 1, doi. 10.1371/journal.pone.0149941
By:
- Visser, W. Edward;
- Bombardieri, Cíntia R.;
- Zevenbergen, Chantal;
- Barnhoorn, Sander;
- Ottaviani, Alexandre;
- van der Pluijm, Ingrid;
- Brandt, Renata;
- Kaptein, Ellen;
- van Heerebeek, Ramona;
- van Toor, Hans;
- Garinis, George A.;
- Peeters, Robin P.;
- Medici, Marco;
- van Ham, Willy;
- Vermeij, Wilbert P.;
- de Waard, Monique C.;
- de Krijger, Ronald R.;
- Boelen, Anita;
- Kwakkel, Joan;
- Kopchick, John J.
Publication type:
Article
Correction: Impaired Genome Maintenance Suppresses the Growth HormoneInsulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome.
Published in:
2008
By:
- van der Pluijm, Ingrid;
- Garinis, George A.;
- Brandt, Renata M. C.;
- Gorgels, Theo G. M. F.;
- Wijnhoven, Susan W.;
- Diderich, Karin E. M.;
- de Wit, Jan;
- Mitchell, James R.;
- van Oostrom, Conny;
- Beems, Rudolf;
- Niedernhofer, Laura J.;
- Velasco, Susana;
- Friedberg, Errol C.;
- Tanaka, Kiyoji;
- van Steeg, Harry;
- Hoeijmakers, Jan H. J.;
- van der Horst, Gijsbertus T. J.
Publication type:
Correction Notice
Impaired Genome Maintenance Suppresses the Growth Hormone--Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome.
Published in:
PLoS Biology, 2007, v. 5, n. 1, p. 23, doi. 10.1371/journal.pbio.0050002
By:
- van der Pluijm, Ingrid;
- Garinis, George A.;
- Brandt, Renata M. C.;
- Gorgels, Theo G. M. F.;
- Wijnhoven, Susan W.;
- Diderich, Karin E. M.;
- de Wit, Jan;
- Mitchell, James R.;
- van Oostrom, Conny;
- Beems, Rudolf;
- Niedernhofer, Laura J.;
- Velasco, Susana;
- Friedberg, Errol C.;
- Tanaka, Kiyoji;
- van Steeg, Harry;
- Hoeijmakers, Jan H. J.;
- van der Horst, Gijsbertus T. J.
Publication type:
Article
Transforming Growth Factor-β and the Renin-Angiotensin System in Syndromic Thoracic Aortic Aneurysms: Implications for Treatment.
Published in:
Cardiovascular Drugs & Therapy, 2021, v. 35, n. 6, p. 1233, doi. 10.1007/s10557-020-07116-4
By:
- van Dorst, Daan C.H.;
- de Wagenaar, Nathalie P.;
- van der Pluijm, Ingrid;
- Roos-Hesselink, Jolien W.;
- Essers, Jeroen;
- Danser, A.H. Jan
Publication type:
Article
Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice.
Published in:
Acta Neuropathologica, 2010, v. 120, n. 4, p. 461, doi. 10.1007/s00401-010-0715-9
By:
- de Waard, Monique C.;
- van der Pluijm, Ingrid;
- Borgesius, Nils Zuiderveen;
- Comley, Laura H.;
- Haasdijk, Elize D.;
- Rijksen, Yvonne;
- Ridwan, Yanto;
- Zondag, Gerben;
- Hoeijmakers, Jan H. J.;
- Elgersma, Ype;
- Gillingwater, Thomas H.;
- Jaarsma, Dick
Publication type:
Article
Dietary restriction but not angiotensin II type 1 receptor blockade improves DNA damage-related vasodilator dysfunction in rapidly aging Ercc1<sup>Δ/−</sup> mice.
Published in:
Clinical Science, 2017, v. 131, n. 15, p. 1941, doi. 10.1042/CS20170026
By:
- Haiyan Wu;
- van Thiel, Bibi S.;
- Bautista-Niño, Paula K.;
- Reiling, Erwin;
- Durik, Matej;
- Leijten, Frank P. J.;
- Ridwan, Yanto;
- Brandt, Renata M.C.;
- van Steeg, Harry;
- Dollé, Martijn E. T.;
- Vermeij, Wilbert P.;
- Hoeijmakers, Jan H. J.;
- Essers, Jeroen;
- van der Pluijm, Ingrid;
- Danser, A. H. Jan;
- Roks, Anton J. M.
Publication type:
Article
Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency.
Published in:
PLoS Genetics, 2014, v. 10, n. 10, p. 1, doi. 10.1371/journal.pgen.1004686
By:
- Barnhoorn, Sander;
- Uittenboogaard, Lieneke M.;
- Jaarsma, Dick;
- Vermeij, Wilbert P.;
- Tresini, Maria;
- Weymaere, Michael;
- Menoni, Hervé;
- Brandt, Renata M. C.;
- de Waard, Monique C.;
- Botter, Sander M.;
- Sarker, Altaf H.;
- Jaspers, Nicolaas G. J.;
- van der Horst, Gijsbertus T. J.;
- Cooper, Priscilla K.;
- Hoeijmakers, Jan H. J.;
- van der Pluijm, Ingrid
Publication type:
Article
Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription- Coupled Repair in Preventing Neuropathology.
Published in:
PLoS Genetics, 2011, v. 7, n. 12, p. 1, doi. 10.1371/journal.pgen.1002405
By:
- Jaarsma, Dick;
- de Waard, Monique C.;
- Haasdijk, Elize D.;
- Brandt, Renata;
- Vermeij, Marcel;
- Rijksen, Yvonne;
- Maas, Alex;
- van Steeg, Harry;
- Hoeijmakers, Jan H. J.;
- van der Horst, Gijsbertus T. J.;
- van der Pluijm, Ingrid
Publication type:
Article
Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms.
Published in:
PLoS Genetics, 2008, v. 4, n. 8, p. 1, doi. 10.1371/journal.pgen.1000161
By:
- Schumacher, Björn;
- van der Pluijm, Ingrid;
- Moorhouse, Michael J.;
- Kosteas, Theodore;
- Robinson, Andria Rasile;
- Yousin Suh;
- Breit, Timo M.;
- van Steeg, Harry;
- Niedernhofer, Laura J.;
- van IJcken, Wilfred;
- Bartke, Andrzej;
- Spindler, Stephen R.;
- Hoeijmakers, Jan H. J.;
- van der Horst, Gijsbertus T. J.;
- Garinis, George A.
Publication type:
Article
Premature aging in mice activates a systemic metabolic response involving autophagy induction.
Published in:
Human Molecular Genetics, 2008, v. 17, n. 14, p. 2196
By:
- Mariño, Guillermo;
- Ugalde, Alejandro P.;
- Salvador-Montoliu, Natalia;
- Varela, Ignacio;
- Quirós, Pedro M.;
- Cadiñanos, Juan;
- van der Pluijm, Ingrid;
- Freije, José M.P.;
- López-Otín, Carlos
Publication type:
Article
Model Systems to Study the Mechanism of Vascular Aging.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 20, p. 15379, doi. 10.3390/ijms242015379
By:
- van der Linden, Janette;
- Trap, Lianne;
- Scherer, Caroline V.;
- Roks, Anton J. M.;
- Danser, A. H. Jan;
- van der Pluijm, Ingrid;
- Cheng, Caroline
Publication type:
Article
Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.
Published in:
Aging Cell, 2024, v. 23, n. 5, p. 1, doi. 10.1111/acel.14126
By:
- van der Linden, Janette;
- Stefens, Sanne J. M.;
- Heredia‐Genestar, José María;
- Ridwan, Yanto;
- Brandt, Renata M. C.;
- van Vliet, Nicole;
- de Beer, Isa;
- van Thiel, Bibi S.;
- Steen, Herman;
- Cheng, Caroline;
- Roks, Anton J. M.;
- Danser, A. H. Jan;
- Essers, Jeroen;
- van der Pluijm, Ingrid
Publication type:
Article
Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model.
Published in:
Aging Cell, 2022, v. 21, n. 9, p. 1, doi. 10.1111/acel.13683
By:
- Ataei Ataabadi, Ehsan;
- Golshiri, Keivan;
- Jüttner, Annika A.;
- de Vries, René;
- Van den Berg‐Garrelds, Ingrid;
- Nagtzaam, Nicole M. A.;
- Khan, Hina N.;
- Leijten, Frank P. J.;
- Brandt, Renata M. C.;
- Dik, Willem A.;
- van der Pluijm, Ingrid;
- Danser, A. H. Jan;
- Sandner, Peter;
- Roks, Anton J. M.
Publication type:
Article
Cockayne Syndrome Group B (Csb) and Group A (Csa) Deficiencies Predispose to Hearing Loss and Cochlear Hair Cell Degeneration in Mice.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 10, p. 4280, doi. 10.1523/JNEUROSCI.5063-14.2015
By:
- Nagtegaal, A. Paul;
- Rainey, Robert N. Rainey;
- van der Pluijm, Ingrid;
- Brandt, Renata M. C.;
- van der Horst, Gijsbertus T. J.;
- Borst, J. Gerard G.;
- Segil, Neil
Publication type:
Article
Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair.
Published in:
Journal of Neuroscience, 2011, v. 31, n. 35, p. 12543, doi. 10.1523/JNEUROSCI.1589-11.2011
By:
- Borgesius, Nils Z.;
- de Waard, Monique C.;
- van der Pluijm, Ingrid;
- Omrani, Azar;
- Zondag, Gerben C. M.;
- van der Horst, Gijsbertus T. J.;
- Melton, David W.;
- Hoeijmakers, Jan H. J.;
- Jaarsma, Dick;
- Elgersma, Ype
Publication type:
Article

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