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- Title
Nächtliche nichtinvasive Beatmung bei Kindern und Jugendlichen mit neuromuskulären Erkrankungen:Einfluss auf Schlaf und Symptome.
- Authors
Mellies, Uwe; Dohna-Schwake, Christian; Ragette, Regine; Teschler, Helmut; Voit, Thomas
- Abstract
Aim: Sleep disordered breathing (SDB) is an inevitable complication of progressive neuromuscular disorders (NMD). Aim of the study was to prospectively investigate the impact of three months of non-invasive ventilation (NIV) on sleep and SDB-associated symptoms in children and adolescents with advanced NMD. Methods: Twenty-two patients (11.1 ± 4.3 years) with symptomatic SDB were enrolled in the study and evaluated with polysomnography and a symptom questionnaire. Twenty patients were treated with pressure assisted ventilation during sleep. The impact of NIV on SDB, sleep and symptoms was re-evaluated after 3 months of NIV. Results: In 2/22 patients, after adenotomy, SDB was no longer demonstrable. In the remaining 20 patients NIV improved SDB (Respiratory Disturbance Index 1.8± 1.6 vs. 9.2±4.5/h; minimal SpO2 91±3 vs. 79±12%). Three months of treatment resulted in shortened sleep latency (17±13 vs. 42±38 minutes), improved sleep efficiency (95±3 vs. 89±9%) and less EEG-arousals (11±5 vs. 22±9/h, p<0.001 for all). Sleep-stage proportion did not change. Patients reported significant improvements of sleep quality, morning headaches, mood, concentration and daytime sleepiness (p < 0.001 for all). Conclusions: In children with NMD intermittent nocturnal NIV results in objective and subjective improvements of sleep quality and symptoms associated with SDB.
- Subjects
NEUROMUSCULAR diseases; NEUROLOGICAL disorders; JUVENILE diseases; POLYSOMNOGRAPHY; SLEEP disorder diagnosis; SYMPTOMS
- Publication
Wiener Klinische Wochenschrift, 2003, Vol 115, Issue 24, p855
- ISSN
0043-5325
- Publication type
Article
- DOI
10.1007/BF03040405