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- Title
Isolation and Identification of FR198248, a Hydroxylated 1,3-Dihydroisobenzofuran, from Aspergillus flavipes as an Inhibitor of Peptide Deformylase.
- Authors
Yun-Ju Kwon; Chang-Ji Zheng; Won-Gon Kim
- Abstract
The article presents a study on the identification and isolation of a hydroxylated 1,3-dihydroisobenzofuran, FR198248, from Aspergillus flavipes as an inhibitor of peptide deformylase (PDF). The study showed that PDF inhibitors have acted as broad-spectrum antibacterial agents. It concludes that 1,3-dihydroisobenzofurans are highly hydroxylated and showed moderate antibacterial activity against Staphylococus aureus.
- Subjects
HYDROXYLATION; STAPHYLOCOCCUS aureus; ASPERGILLUS flavus; ANTIBACTERIAL agents; ANTI-infective agents
- Publication
Bioscience, Biotechnology & Biochemistry, 2010, Vol 74, Issue 2, p390
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.90565