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- Title
Control of Glycopolymer Nanoparticle Morphology by a One-Pot, Double Modification Procedure Using Thiolactones.
- Authors
Chen, Yong; Espeel, Pieter; Reinicke, Stefan; Du Prez, Filip E.; Stenzel, Martina H.
- Abstract
A copolymer from N-isopropylacryl amide (NIPAAm) and N-homocysteine thiolactone acrylamide (TlaAm), prepared by RAFT polymerization, is reacted with various amines, bearing alkyl residues of increasing length ( n-propylamine, n-hexylamine, and n-dodecylamine) to liberate the corresponding thiol, which is consequently reacted in situ with 2-bromoethyl-2′,3′,4′,6′-tetra- O-acetyl-α- d-mannopyranoside. The resulting double-modified graft copolymers show characteristic self-assembly behavior due to their amphiphilic nature, affording glycopolymer-based nanoparticles. While the n-propylamine-derived amphiphiles mainly lead to micelles (30 nm), the n-hexylamine adducts give rise to larger vesicles (200-600 nm). Longer alkyl amines result in the formation of large compound micelles. The assembled nanoparticles are bioactive and interact effectively with Concanavalin A (ConA).
- Subjects
POLYMERS; NANOPARTICLES; SURFACE morphology; POLYMERIZATION; GRAFT copolymers; AMPHIPHILES
- Publication
Macromolecular Rapid Communications, 2014, Vol 35, Issue 12, p1128
- ISSN
1022-1336
- Publication type
Article
- DOI
10.1002/marc.201400110