We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Iron‐Catalyzed Cross‐Coupling of Thioesters and Organomanganese Reagents**.
- Authors
Geiger, Valentin Jacob; Lefèvre, Guillaume; Fleischer, Ivana
- Abstract
We report a Fukuyama‐type coupling of thioesters with aliphatic organomanganese reagents utilizing a cheap and easily available iron(III) precatalyst. The reactions exhibit a wide tolerance of solvents and functional groups, allowing for the conversion of thioesters derived from natural products and pharmaceutical compounds. A strong steric impact from each reaction component (carboxylic moiety, thiol substituent and manganese reagent) was displayed, which enabled regioselective transformation of dithioesters. Mechanistic investigations showed that the released thiolate does not act as a mere spectator ligand, but rather positively influences the stability of intermediate alkyl(II)ferrates.
- Subjects
THIOESTERS; IRON; FERRITES; NATURAL products; FUNCTIONAL groups; ORGANOCATALYSIS
- Publication
Chemistry - A European Journal, 2022, Vol 28, Issue 62, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202202212