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- Title
Cover Feature: Five‐Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020).
- Authors
Patel, Niki R.; Huffman, Mark A.; Wang, Xiao; Ding, Bangwei; McLaughlin, Mark; Newman, Justin A.; Andreani, Teresa; Maloney, Kevin M.; Johnson, Heather C.; Whittaker, Aaron M.
- Abstract
Cover Feature: Five-Step Enantioselective Synthesis of Islatravir via Asymmetric Ketone Alkynylation and an Ozonolysis Cascade (Chem. Eur. J. 62/2020) Keywords: asymmetric alkynylation; biocatalysis; ozonolysis; synthesis EN asymmetric alkynylation biocatalysis ozonolysis synthesis 14023 14023 1 11/12/20 20201106 NES 201106 B A ball-and-stick Houk-style view of islatravir b , the target of the total synthesis described in this work, is depicted in the cover image. In the center of the picture is a circle showing the three key catalytic steps of the synthesis; a biocatalytic cascade, an enantioselective alkynylation, and an ozonolysis deprotection cascade.
- Subjects
OZONOLYSIS; HIV; KETONES; ASYMMETRIC synthesis
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 62, p14023
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202003600