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- Title
Adenosine usage during AF ablation in Europe and selected long-term findings from the ESC-EHRA EORP Atrial Fibrillation Ablation Long-Term registry.
- Authors
van Rosmalen, Frank; Delhaas, Tammo; Dagres, Nikolaos; Arbelo, Elena; Blomström-Lundqvist, Carina; Crijns, Harry J. G. M.; Da Costa, Antoine; Pytkowski, Mariusz; Sharikov, Nikita; Laroche, Cécile; Tavazzi, Luigi; Brugada, Joseph; Pison, Laurent; ESC-EHRA Atrial Fibrillation Ablation Long-Term Registry investigators
- Abstract
<bold>Background: </bold>Adenosine can be used to reveal dormant pulmonary vein (PV) conduction after PV isolation (PVI). This study presents a subanalysis of real-world 1-year follow-up data from the ESC-EHRA EORP Atrial Fibrillation (AF) Ablation Long-Term registry to analyze the usage of adenosine during PVI treatment in terms of rhythm outcome and safety.<bold>Methods: </bold>The registry consists of 104 participating centers in 27 countries within the European Society of Cardiology. The registry data was split into an adenosine group (AG) and no-adenosine group (NAG). Procedure characteristics and patient outcome were compared.<bold>Results: </bold>Adenosine was administered in 10.8% of the 3591 PVI patients included in the registry. Spain, the Netherlands, and Italy included the majority of adenosine cases (48.8%). Adenosine was applied more often in combination with open irrigation radiofrequency (RF) energy (74.7%) and less often in combination with nonirrigated RF energy (1.6%). After 1 year, a higher percentage of the AG was free from AF compared with the NAG (68.9% vs 59.1%, p < 0.001). Adenosine was associated with better rhythm outcome in RF ablation procedures, but not in cryo-ablation procedures (freedom from AF: RF: AG: 70.9%, NAG: 58.1%, p < 0.001, cryo: AG: 63.9%, NAG: 63.8%, p = 0.991).<bold>Conclusions: </bold>The use of adenosine was associated with a better rhythm outcome after 1 year follow-up and seems more useful in patients treated with RF energy compared with patients treated with cryo energy. Given the improved rhythm outcome at 1-year follow-up, it seems reasonable to encourage the use of adenosine during RF AF ablation.
- Subjects
ATRIAL fibrillation; ADENOSINES; EUROPEAN Society of Cardiology; PULMONARY veins; MEDICAL registries; CATHETER ablation; ACQUISITION of data; TREATMENT effectiveness; DISEASE relapse
- Publication
Journal of Interventional Cardiac Electrophysiology, 2021, Vol 60, Issue 3, p395
- ISSN
1383-875X
- Publication type
journal article
- DOI
10.1007/s10840-020-00744-8