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- Title
Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: Initial experience.
- Authors
Oberholzer, Katja; Pohlmann, Andreas; Schreiber, Wolfgang; Mildenberger, Peter; Kunz, Peter; Schmidberger, Heinz; Junginger, Theodor; Düber, Cristoph
- Abstract
Purpose To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer. Materials and Methods A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma. Results Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k21, P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate ( P = 0.005), while amplitude A increased moderately after therapy ( P = 0.136). Conclusion DCE-MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring. J. Magn. Reson. Imaging 2008;27:1296-1301. © 2008 Wiley-Liss, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2008, Vol 27, Issue 6, p1296
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.21305