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- Title
Disease activity and mucosal healing in inflammatory bowel disease: a new role for histopathology?
- Authors
Pai, Rish K.; Geboes, Karel
- Abstract
Histologic evaluation of disease activity in the setting of inflammatory bowel disease is gaining interest within the gastroenterology community. Recent data suggests that histologic measurements of inflammation in ulcerative colitis are more sensitive at detecting disease activity and perform better than endoscopic measurements in predicting clinical outcomes. Histologic measurements are also increasingly used in ulcerative colitis clinical trials to assess response to new therapies. Histologic measurements of disease activity are less well studied in Crohn's disease, but are gaining attention. Current published treatment algorithms in inflammatory bowel disease do not take into consideration histologic activity; however, this may change in the near future. In order for histologic measurements to be included in clinical decision-making, validated, reliable, and responsive histologic scoring systems are needed. In this review, the recent literature on the significance of histologic activity in both ulcerative colitis and Crohn's disease is summarized. Histologic scoring systems are also briefly discussed.
- Subjects
INFLAMMATORY bowel disease diagnosis; CYTODIAGNOSIS; HISTOLOGICAL techniques; INFLAMMATORY bowel diseases; INTESTINAL mucosa; PATHOLOGY; WOUND healing
- Publication
Virchows Archiv: European Journal of Pathology, 2018, Vol 472, Issue 1, p99
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-017-2156-5