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- Title
Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements.
- Authors
Martelli, Fabrizio; Del Bianco, Samuele; Spinelli, Lorenzo; Cavalieri, Stefano; Di Ninni, Paola; Binzoni, Tiziano; Jelzow, Alexander; Macdonald, Rainer; Wabnitz, Heidrun
- Abstract
In this work, we have tested the optimal estimation (OE) algorithm for the reconstruction of the optical properties of a two-layered liquid tissue phantom from time-resolved single-distance measurements. The OE allows a priori information, in particular on the range of variation of fit parameters, to be included. The purpose of the present investigations was to compare the performance of OE with the Levenberg-Marquardt method for a geometry and real experimental conditions typically used to reconstruct the optical properties of biological tissues such as muscle and brain. The absorption coefficient of the layers was varied in a range of values typical for biological tissues. The reconstructions performed demonstrate the substantial improvements achievable with the OE provided a priori information is available. We note the extreme reliability, robustness, and accuracy of the retrieved absorption coefficient of the second layer obtained with the OE that was found for up to six fit parameters, with an error in the retrieved values of less than 10%. A priori information on fit parameters and fixed forward model parameters clearly improves robustness and accuracy of the inversion procedure.
- Subjects
CELL imaging; IMAGING phantoms; TIME-resolved spectroscopy; OPTICAL properties; IMAGE reconstruction
- Publication
Journal of Biomedical Optics, 2015, Vol 20, Issue 11, p115001-1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.20.11.115001