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- Title
Shear wave pulse compression for dynamic elastography using phase-sensitive optical coherence tomography.
- Authors
Thu-Mai Nguyen; Shaozhen Song; Arnal, Bastien; Wong, Emily Y.; Zhihong Huang; Ruikang K. Wang; O'Donnell, Matthew
- Abstract
Assessing the biomechanical properties of soft tissue provides clinically valuable information to supplement conventional structural imaging. In the previous studies, we introduced a dynamic elastography technique based on phase-sensitive optical coherence tomography (PhS-OCT) to characterize submillimetric structures such as skin layers or ocular tissues. Here, we propose to implement a pulse compression technique for shear wave elastography. We performed shear wave pulse compression in tissue-mimicking phantoms. Using a mechanical actuator to generate broadband frequency-modulated vibrations (1 to 5 kHz), induced displacements were detected at an equivalent frame rate of 47 kHz using a PhS-OCT. The recorded signal was digitally compressed to a broadband pulse. Stiffness maps were then reconstructed from spatially localized estimates of the local shear wave speed. We demonstrate that a simple pulse compression scheme can increase shear wave detection signal-to-noise ratio (>12 dB gain) and reduce artifacts in reconstructing stiffness maps of heterogeneous media.
- Subjects
OPTICAL coherence tomography; PULSE compression (Signal processing); SHEAR waves; TISSUES; TOMOGRAPHY
- Publication
Journal of Biomedical Optics, 2014, Vol 19, Issue 1, p1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.19.1.016013