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- Title
SOCE in the cardiomyocyte: the secret is in the chambers.
- Authors
Rosenberg, Paul; Zhang, Hengtao; Bryson, Victoria Graham; Wang, Chaojian
- Abstract
Store-operated Ca2+ entry (SOCE) is an ancient and ubiquitous Ca2+ signaling pathway that is present in virtually every cell type. Over the last two decades, many studies have implicated this non-voltage dependent Ca2+ entry pathway in cardiac physiology. The relevance of the SOCE pathway in cardiomyocytes is often questioned given the well-established role for excitation contraction coupling. In this review, we consider the evidence that STIM1 and SOCE contribute to Ca2+ dynamics in cardiomyocytes. We discuss the relevance of this pathway to cardiac growth in response to developmental and pathologic cues. We also address whether STIM1 contributes to Ca2+ store refilling that likely impacts cardiac pacemaking and arrhythmogenesis in cardiomyocytes.
- Publication
Pflügers Archiv: European Journal of Physiology, 2021, Vol 473, Issue 3, p417
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-021-02540-3