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- Title
Absolute choline concentration measured by quantitative proton MR spectroscopy correlates with cell density in meningioma.
- Authors
Qiang Yue; Shibata, Yasushi; Isobe, Tomonori; Anno, Izumi; Kawamura, Hiraku; Qi-Yong Gong; Matsumura, Akira
- Abstract
This study was aimed to investigate the relationship between quantitative proton magnetic resonance spectroscopy (1H-MRS) and pathological changes in meningioma. Twenty-two meningioma cases underwent single voxel 1H-MRS (point-resolved spectroscopy sequence, repetition time/echo time = 2,000 ms/68, 136, 272 ms). Absolute choline (Cho) concentration was calculated using tissue water as the internal reference and corrected according to intra-voxel cystic/necrotic parts. Pathological specimens were stained with MIB-1 antibody to measure cell density and proliferation index. Correlation analysis was performed between absolute Cho concentration and cell density and MIB-1 labeled proliferation index. Average Cho concentration of all meningiomas before correction was 2.95 ± 0.86 mmol/kg wet weight. It was increased to 3.23 ± 1.15 mmol/kg wet weight after correction. Average cell density of all meningiomas was 333 ± 119 cells/HPF, and average proliferation index was 2.93 ± 5.72%. A linear, positive correlation between cell density and Cho concentration was observed ( r = 0.650, P = 0.001). After correction of Cho concentration, the correlation became more significant ( r = 0.737, P < 0.001). However, no significant correlation between Cho concentration and proliferation index was found. There seemed to be a positive correlation trend after correction of Cho concentration but did not reach significant level. Absolute Cho concentration, especially Cho concentration corrected according to intra-voxel cystic/necrotic parts, reflects cell density of meningioma.
- Subjects
MENINGIOMA; PROTON magnetic resonance spectroscopy; CHOLINE; CELLS; BRAIN tumors
- Publication
Neuroradiology, 2009, Vol 51, Issue 1, p61
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-008-0461-z