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- Title
Circulating osteoprotegerin and receptor activator of NF-κB ligand system in patients with β-thalassemia major.
- Authors
Nicholas G. Angelopoulos; Anastasia Goula; Eugenia Katounda; Grigorios Rombopoulos; Victoria Kaltzidou; Dimitrios Kaltsas; Sophia Malaktari; Vassilis Athanasiou; George Tolis
- Abstract
Abstract??Osteoporosis represents an important cause of morbidity in patients with ?-thalassemia major, and its etiology is multifactorial. Thus, the aim of this study was to characterize the possible role of the osteoprotegerin (OPG) and receptor activator of the NF-?B ligand (RANKL) system in thalassemia-related bone loss. Serum concentrations of OPG, soluble RANKL (s-RANKL), markers of bone turnover, and lumbar spine bone mineral density (BMD) were measured in random samples of males (n= 29; mean age ? SEM, 24.26 ? 1.29 years; range, 13?41 years) and females (n= 31; age, 24.59 ? 0.95 years; range, 12?34 years) with ?-thalassemia major and in 30 healthy age-, height-, and weight-matched subjects. Thalassemic patients had significantly lower levels of OPG compared with controls (2.54 ? 0.12 vs. 3.25 ? 0.122, respectively;PPr= ?0.3,Pr= 0.52,P(r= 0.40, Pr= ?0.55,P
- Subjects
THALASSEMIA; HEMOGLOBINOPATHY; BONE diseases; HEMOLYTIC anemia
- Publication
Journal of Bone & Mineral Metabolism, 2007, Vol 25, Issue 1, p60
- ISSN
0914-8779
- Publication type
Article