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- Title
Metabolic engineering of non-pathogenic microorganisms for 2,3-butanediol production.
- Authors
Lee, Jae Won; Lee, Ye-Gi; Jin, Yong-Su; Rao, Christopher V.
- Abstract
2,3-Butanediol (2,3-BDO) is a promising commodity chemical with various industrial applications. While petroleum-based chemical processes currently dominate the industrial production of 2,3-BDO, fermentation-based production of 2,3-BDO provides an attractive alternative to chemical-based processes with regards to economic and environmental sustainability. The achievement of high 2,3-BDO titer, yield, and productivity in microbial fermentation is a prerequisite for the production of 2,3-BDO at large scales. Also, enantiopure production of 2,3-BDO production is desirable because 2,3-BDO stereoisomers have unique physicochemical properties. Pursuant to these goals, many metabolic engineering strategies to improve 2,3-BDO production from inexpensive sugars by Klebsiella oxytoca, Bacillus species, and Saccharomyces cerevisiae have been developed. This review summarizes the recent advances in metabolic engineering of non-pathogenic microorganisms to enable efficient and enantiopure production of 2,3-BDO. Key points: • K. oxytoca, Bacillus species, and S. cerevisiae have been engineered to achieve efficient 2,3-BDO production. • Metabolic engineering of non-pathogenic microorganisms enabled enantiopure production of 2,3-BDO. • Cost-effective 2,3-BDO production can be feasible by using renewable biomass.
- Subjects
KLEBSIELLA oxytoca; BUTANEDIOL; CHEMICAL processes; SUSTAINABLE development; ENGINEERS
- Publication
Applied Microbiology & Biotechnology, 2021, Vol 105, Issue 14/15, p5751
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-021-11436-2