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- Title
Identification and production of a novel natural pigment, cordycepoid A, from Cordyceps bifusispora.
- Authors
Lu, Rui-Li; Luo, Fei-Fei; Hu, Feng-Lin; Huang, Bo; Li, Chun-Ru; Bao, Guan-Hu
- Abstract
A novel yellow pigment, cordycepoid A, was isolated and identified from the entomogenous fungi Cordyceps bifusispora. Cordycepoid A exhibited no significant toxicity against Chinese hamster ovary (CHO) cells and mice, and showed high stability against food addictives, metal ions and heat. A liquid/solid double-phase cultural process for the production of the pigment was optimized as follows: 3 days aged liquid seed, 7.5 % inoculums, incubation temperature at 25 °C, 10 days of solid culture, and the last 5 days exposed to 200 Lx scattered light. The liquid seed medium and the solid culture medium were also optimized. Ethanol was selected as extracting solvent for its scale-up production. The optimal extracting conditions were determined as liquid/solid ratio at 20:1, extracting temperature at 40 °C, ultrasonic power at 400 W, and extracting time of 40 min.
- Subjects
CORDYCEPS; LABORATORY mice; METAL ions; TEMPERATURE effect; SOLID-liquid interfaces; SOLVENTS
- Publication
Applied Microbiology & Biotechnology, 2013, Vol 97, Issue 14, p6241
- ISSN
0175-7598
- Publication type
Article
- DOI
10.1007/s00253-013-4966-y