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- Title
Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis.
- Authors
Mishina, Masayoshi; Tobimatsu, Takamasa; Imoto, Keiji; Tanaka, Ken-ichi; Fujita, Yoshihiko; Fukuda, Kazuhiko; Kurasaki, Masaaki; Takahashi, Hideo; Morimoto, Yuuki; Hirose, Tadaaki; Inayama, Seiichi; Takahashi, Tomoyuki; Kuno, Motoy; Numa, Shosaku
- Abstract
The availability of cloned cDNAs encoding the four subunits of the Torpedo acetylcholine receptor, which can be expressed to make functional receptors in Xenopus oocytes, has made possible a detailed investigation of the functions of the different structural components of the receptor. The functional analysis of receptors with α-subunits altered at specific sites by site-directed mutagenesis of the cDNA has allowed the location of specific regions of the α-subunit molecule involved in acetylcholine binding and forming a transmembrane ionic channel.
- Publication
Nature, 1985, Vol 313, Issue 6001, p364
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/313364a0