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- Title
A New Diarylheptanoid from the Twigs of Quercus Acutissima and their Neuroprotective Activity.
- Authors
Cha, Joon Min; Subedi, Lalita; Khan, Zahra; Kim, Sun Yeou; Lee, Kang Ro
- Abstract
A new diarylheptanoid glycoside, acutissioside A (4), along with five known diarylheptanoids (1–3, 5, 6) was isolated from the twigs of Quercus acutissima Carruth. The structure of the new compound was determined via spectral analysis, including NMR spectra (1H and 13C NMR, 1H–1H COSY, HSQC, HMBC) and HR-ESI-MS, acid hydrolysis, and specific optical rotation data. The neuroprotective effect of all the diarylheptanoid compounds (1–6) was evaluated. Compound 1 exhibited NGF secretion to 154.60 ± 2.87%, which was stronger than that of the positive control 6-shogaol (140.45 ± 2.18%).
- Subjects
TWIGS; OPTICAL rotation; GLYCOSIDES
- Publication
Chemistry of Natural Compounds, 2020, Vol 56, Issue 2, p213
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-020-02990-8