We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after trastuzumab-based chemotherapy for HER2-positive gastric cancer: a case report.
- Authors
Nagata, Hiromi; Tsujimoto, Hironori; Yaguchi, Yoshihisa; Kouzu, Keita; Itazaki, Yujiro; Ishibashi, Yusuke; Tsuchiya, Satoshi; Sugihara, Takao; Ito, Nozomi; Harada, Manabu; Nomura, Shinsuke; Utsumi, Yoshitaka; Shimazaki, Hideyuki; Kishi, Yoji; Ueno, Hideki
- Abstract
Background: Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after T-mab-based chemotherapy for HER2-positive gastric cancer. Case presentation: A 60-year-old man presented with a mass of the upper abdomen, which was diagnosed as adenocarcinoma with a HER2 score of 3+ by endoscopic biopsy. He received seven cycles of combination chemotherapy with capecitabine, cisplatin, and T-mab. Subsequently, he underwent open total gastrectomy, distal pancreatosplenectomy, and extended left hepatic lobectomy as a conversion surgery. The surgically resected specimen demonstrated both adenocarcinoma and neuroendocrine components; therefore, it was diagnosed as HER2-negative mixed adenoneuroendocrine carcinoma. Although the patient received additional chemotherapy, multiple liver metastases appeared at 3 months postoperatively and he died at 6 months postoperatively because of the rapidly progressing metastatic tumor. Conclusions: We encountered a rare case of rapidly progressive mixed adenoneuroendocrine carcinoma that was negative for HER2 expression after T-mab treatment combined with chemotherapy.
- Subjects
STOMACH cancer; CARCINOMA; CANCER chemotherapy; COMBINATION drug therapy; LIVER metastasis; MERKEL cell carcinoma
- Publication
Surgical Case Reports, 2020, Vol 6, Issue 1, p1
- ISSN
2198-7793
- Publication type
Article
- DOI
10.1186/s40792-020-0774-7