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- Title
Preparation of cordycepin nanoemulsion and its repair mechanism on the photoaged skin.
- Authors
Hucheng Zhang; Guowei Yang; Jun Yang; Haitao Fan; Shuai Luo; Linying Liu
- Abstract
Cordycepin was used as an effective component to prepare nanoemulsion. The formulation process, preliminary quality evaluation and skin photoaging repair mechanism of cordycepin nanoemulsion were studied. By drawing the pseudo ternary phase diagram, the formula of the nanoemulsion was determined. The particle size, viscosity, and stability of the nanoemulsion were investigated. The activity of superoxide dismutase (SOD), glutathione(GSH), catalase(CAT)and the content of malondialdehyde(MDA)in the skin of New Zealand rabbits were measured. The results show that the nanoemulsion is stable when the Km of surfactant and co-surfactant is 2:1. The average diameter of cordycepin nanoemulsion is 374 nm and the viscosity is(9.33±0.14) mPa's. It has good centrifugal stability, dilution stability, long-term stability and temperature stability. Cordycepin can be maintained at (12.006±0.025)mg/g for DNA damage Aggregation 飜~~~辔- * Proteolyse Protein damage 4-hydroxynonenal OH / O Lipid damage MDA Epidermis Cordycepin CAT SOD Epidermis N N 1-8 months with the RSD within 1%, and it begins to decrease in the ninth month. The activities of SOD, CAT and GSH in group 4 using cordycepin nanoemulsion are slightly lower than those in the control group, significantly higher than those in groups 1, 2 and 3 (P<0.01). The MDA in the control group and group 4 are significantly lower than those in groups 1, 2 and 3 (P<0.01). Cordycepin nanoemulsion has good stability, viscosity and particle size, and can effectively alleviate skin aging caused by ultraviolet radiation. This study aims to lay a theoretical foundation and provide direction for the further development of the function of cordycepin nanoemulsion.
- Subjects
NEW Zealand; TERNARY phase diagrams; EMULSION paint; SKIN aging; HIGH performance liquid chromatography; SUPEROXIDE dismutase
- Publication
China Surfactant Detergent & Cosmetics (1001-1803), 2022, Vol 52, Issue 10, p1072
- ISSN
1001-1803
- Publication type
Article
- DOI
10.3969/j.issn.1001-1803.2022.10.006