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- Title
Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline.
- Authors
Nair, Ajay Kumar; Van Hulle, Carol A.; Bendlin, Barbara B.; Zetterberg, Henrik; Blennow, Kaj; Wild, Norbert; Kollmorgen, Gwendlyn; Suridjan, Ivonne; Busse, William W.; Rosenkranz, Melissa A.
- Abstract
Introduction: Evidence from epidemiology, neuroimaging, and animal models indicates that asthma adversely affects the brain, but the nature and extent of neuropathophysiological impact remain unclear. Methods: We tested the hypothesis that asthma is a risk factor for dementia by comparing cognitive performance and cerebrospinal fluid biomarkers of glial activation/neuroinflammation, neurodegeneration, and Alzheimer's disease (AD) pathology in 60 participants with asthma to 315 non-asthma age-matched control participants (45-93 years), in a sample enriched for AD risk. Results: Participants with severe asthma had higher neurogranin concentrations compared to controls and those with mild asthma. Positive relationships between cardiovascular risk and concentrations of neurogranin and α-synuclein were amplified in severe asthma. Severe asthma also amplified the deleterious associations that apolipoprotein E ε4 carrier status, cardiovascular risk, and phosphorylated tau181/amyloid beta42 have with rate of cognitive decline. Discussion: Our data suggest that severe asthma is associated with synaptic degeneration andmay compound risk for dementia posed by cardiovascular disease and genetic predisposition.
- Subjects
DISEASE risk factors; COGNITION disorders; ALZHEIMER'S disease; APOLIPOPROTEIN E; DISEASE susceptibility; MILD cognitive impairment
- Publication
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, Vol 8, Issue 1, p1
- ISSN
2352-8737
- Publication type
Article
- DOI
10.1002/trc2.12315