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- Title
Toxoplasma gondii infection of the central nervous system and suicide: A case-control study of decedents.
- Authors
ALEJANDRA MENDOZA-LARIOS, LAURA; GARCÍA-DOLORES, FERNANDO; FRANCISCO SÁNCHEZ-ANGUIANO, LUIS; IRASEMA ANTUNA-SALCIDO, ELIZABETH; HERNÁNDEZ-TINOCO, JESÚS; ROCHA-SALAIS, ADRIANA; ARACELI SEGOVIANO-MENDOZA, MARCELA; SIFUENTES-ÁLVAREZ, ANTONIO; ALVARADO-ESQUIVEL, COSME
- Abstract
We sought to determine the association between Toxoplasma gondii (T. gondii) infection of the central nervous system and suicide in a sample of decedents in Mexico City. One hundred and forty-seven decedents (87 who committed suicide and 60 who did not commit suicide) were studied. Brain tissues (amygdala and prefrontal cortex) of decedents were examined for the detection of T. gondii using immunohistochemistry. Detection of T. gondii was positive in 7 (8.0%) of the 87 cases (6 found in prefrontal cortex and one in amygdala), and in one (1.7%) of the 60 controls (found in prefrontal cortex) (OR: 5.16; 95% CI: 0.61–43.10; P 5 0.14). Results suggest that T. gondii infection in brain is not associated with suicide. Further studies to confirm this finding are needed.
- Subjects
TOXOPLASMA gondii; CENTRAL nervous system infections; SUICIDE; CENTRAL nervous system; IMMUNOHISTOCHEMISTRY; EPIDEMIOLOGY; AMYGDALOID body; PREFRONTAL cortex
- Publication
European Journal of Microbiology & Immunology, 2023, Vol 13, Issue 3, p77
- ISSN
2062-509X
- Publication type
Article
- DOI
10.1556/1886.2023.00033