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- Title
Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains.
- Authors
YURTTAŞ, Leyla; ÖZKAY, Yusuf; DEMİRCİ, Fatih; GÖGER, Gamze; ULUSOYLAR YILDIRIM, Şafak; ABU MOHSEN, Usama; ÖZTÜRK, Ömer; KAPLANCIKLI, Zafer Asım
- Abstract
Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by spectral data (IR, ¹H NMR, 13C NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a-j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 Δg/mL.
- Subjects
THIAZOLE derivatives; DITHIOCARBAMATES synthesis; SUBSTITUENTS (Chemistry); CARBAMIC acid; CELL-mediated cytotoxicity
- Publication
Turkish Journal of Chemistry, 2014, Vol 38, Issue 5, p815
- ISSN
1300-0527
- Publication type
Article
- DOI
10.3906/kim-1312-62