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- Title
Multidirectional Pharma-Toxicological Study on Harpagophytum procumbens DC. ex Meisn.: An IBD-Focused Investigation.
- Authors
Recinella, Lucia; Chiavaroli, Annalisa; Ronci, Maurizio; Menghini, Luigi; Brunetti, Luigi; Leone, Sheila; Tirillini, Bruno; Angelini, Paola; Covino, Stefano; Venanzoni, Roberto; Zengin, Gokhan; Simone, Simonetta Di; Ciferri, Maria Chiara; Giacomo, Viviana di; Cataldi, Amelia; Rapino, Monica; Valerio, Valentina Di; Orlando, Giustino; Ferrante, Claudio
- Abstract
In the present study, we investigated the water extract of Harpagophytum procumbens DC. ex Meisn. in an experimental model of inflammatory bowel diseases (IBDs). Additionally, a microbiological investigation was carried out to discriminate the efficacy against bacterial and fungal strains involved in IBDs. Finally, an untargeted proteomic analysis was conducted on more than one hundred colon proteins involved in tissue morphology and metabolism. The extract was effective in blunting the production of oxidative stress and inflammation, including serotonin, prostaglandins, cytokines, and transcription factors. Additionally, the extract inhibited the growth of Candida albicans and C. tropicalis. The extract was also able to exert a pro-homeostatic effect on the levels of a wide plethora of colon proteins, thus corroborating a protective effect. Conversely, the supraphysiological downregulation of cytoskeletal-related proteins involved in tissue morphology and antimicrobial barrier function suggests a warning in the use of food supplements containing H. procumbens extracts.
- Subjects
INFLAMMATORY bowel diseases; INVESTIGATIONS; TISSUE metabolism; DIETARY supplements; CANDIDEMIA; TRANSCRIPTION factors; COLON (Anatomy)
- Publication
Antioxidants, 2020, Vol 9, Issue 2, p168
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox9020168