We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis.
- Authors
Egesie, Ochaka; Agaba, Patricia; Silas, Olugbenga; Achenbach, Chad; Zoakah, Ayuba; Agbaji, Oche; Madaki, Jeremiah; Okeke, Edith; Hou, Lifang; Sagay, Atiene; Murphy, Robert
- Abstract
Background: Hematologic malignancies cause significant morbidity and mortality and are not uncommon in resource-limited low-income countries. However, the types, pattern of presentation, and treatment outcomes vary across regions. We assessed the presentation and overall survival (OS) over an 11-year period in adult patients with hematologic cancers in Jos, North Central Nigeria. Materials: and Methods This retrospective outcome study evaluated patients who presented with hematologic malignancies between 2005 and 2015 at the Jos University Teaching Hospital, Jos. Variables of interest were abstracted through chart reviews. Descriptive statistics were used to evaluate baseline and follow-up parameters. OS was assessed by using Kaplan–Meier method. Results: Sixty patients, contributing 25,994 person-days of follow-up were evaluated. The mean age was 43 ± 17 years and 61.7% were males. Thirty-one patients (51.7%) presented with leukemia, 45.0% with lymphoma, and 3.3% with multiple myeloma. Forty-two (70.0%) presented with advanced disease, 5 (5.2%) were human immunodeficiency virus positive and 4 (6.7%) had died at the end of follow-up. OS was 84.3% (95% confidence interval: 58.1–94.7). Survival differed by disease group (P = 0.01) and having fever at presentation (P = 0.02). Conclusion: We found long-term OS to be impacted by disease type and status of fever at presentation. Disease-specific strategies to improve early diagnosis and therapies are needed to ensure optimal outcomes in Nigerian patients.
- Publication
Journal of Medicine in the Tropics, 2018, Vol 20, Issue 1, p49
- ISSN
2276-7096
- Publication type
Article
- DOI
10.4103/jomt.jomt_8_18