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- Title
Cardiorespiratory Fitness, Adiposity, and Cancer Mortality in Men.
- Authors
Vainshelboim, Baruch; Chen, Zhongming; Lee, Yvonne Nicole; Sorayya, Aryo; Kokkinos, Peter; Nead, Kevin T.; Chester, Cariad; Myers, Jonathan
- Abstract
<bold>Objective: </bold>This study sought to evaluate the association between cardiorespiratory fitness (CRF) and cancer mortality in men with overweight and obesity.<bold>Methods: </bold>Maximal exercise testing was performed in 3,610 men (58.8 ± 17.5 years) (n = 2,100 with overweight and n = 1,510 with obesity) free from malignancy at baseline who were followed for 12.3 ± 7.4 years. Body mass index of 25.0 to 29.9 kg/m2 for overweight and ≥ 30.0 for obesity categories was used. Hazard ratios and population-attributable risks (PAR) were determined.<bold>Results: </bold>During the follow-up period, 11.1% and 9.1% died from cancer among those who had overweight and obesity, respectively. CRF had an inverse and graded association with cancer mortality. Compared with low CRF (< 5 metabolic equivalents), moderate and high CRF levels were associated with 48% and 79% reduced risks for cancer mortality in men who had overweight (P < 0.001) and 55% and 83% lower risks in those who had obesity (P < 0.001), respectively. Low CRF had PARs of 9.3% and 10.5% for cancer mortality in subjects who had overweight and obesity, respectively.<bold>Conclusions: </bold>Among men with overweight and obesity, higher CRF is associated with lower cancer mortality. Eliminating low CRF as a risk factor would potentially prevent a considerable number of cancer deaths and reduce the associated societal and economic burden in these high-risk populations.
- Subjects
UNITED States; OBESITY; BODY mass index; CANCER-related mortality; PHYSICAL activity; SMOKING; OBESITY complications; ADIPOSE tissues; HUMAN body composition; LONGITUDINAL method; VETERANS; SURVIVAL analysis (Biometry); TUMORS; DISEASE complications
- Publication
Obesity (19307381), 2017, Vol 25, pS66
- ISSN
1930-7381
- Publication type
journal article
- DOI
10.1002/oby.22009