We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
MicroRNAs associated with postoperative outcomes in patients with limited stage neuroendocrine carcinoma of the esophagus.
- Authors
Okumura, Tomoyuki; Fujii, Tsutomu; Terabayashi, Kenji; Kojima, Takashi; Takeda, Shigeru; Kashiwada, Tomomi; Toriyama, Kazuhiro; Hijioka, Susumu; Miyazaki, Tatsuya; Yamamoto, Miho; Tanabe, Shunsuke; Shirakawa, Yasuhiro; Furukawa, Masayuki; Honma, Yoshitaka; Hoshino, Isamu; Nabeya, Yoshihiro; Yamaguchi, Hironori; Uemoto, Shinji; Shimada, Yutaka; Matsubara, Hisahiro
- Abstract
Esophageal neuroendocrine carcinoma (E-NEC) is an aggressive disease with a poor prognosis. The present study aimed to assess the role of surgery in the treatment of patients with resectable E-NEC, and identify a microRNA (miRNA/miR) signature in association with positive postoperative outcomes. Between February 2017 and August 2019, 36 patients with E-NEC who underwent curative surgery at the Japan Neuroendocrine Tumor Society partner hospitals were enrolled in the study. A total of 16 (44.4%) patients achieved disease-free survival (non-relapse group), whereas 20 (55.6%) patients developed tumor relapse (relapse group) during the median follow-up time of 36.5 months (range, 1–242) after surgery with a 5-year overall survival rate of 100 and 10.8%, respectively (P<0.01). No clinicopathological parameters, such as histological type or TNM staging, were associated with tumor relapse. Microarray analysis of 2,630 miRNAs in 11 patients with sufficient quality RNA revealed 12 miRNAs (miR-1260a, −1260b, −1246, −4284, −612, −1249-3p, −296-5p, −575, −6805-3p, −12136, −6822-5p and −4454) that were differentially expressed between the relapse (n=6) and non-relapse (n=5) groups. Furthermore, the top three miRNAs (miR-1246, −1260a and −1260b) were associated with overall survival (P<0.01). These results demonstrated that surgery-based multidisciplinary treatment is effective in a distinct subpopulation of limited stage E-NEC. A specific miRNA gene set is suggested to be associated with treatment outcome.
- Subjects
NEUROENDOCRINE tumors; TREATMENT effectiveness; ESOPHAGUS; MICRORNA; PROGRESSION-free survival; DNA microarrays
- Publication
Oncology Letters, 2023, Vol 26, Issue 1, pN.PAG
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2023.13862