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- Title
Calcitonin gene-related peptide: A promising bridge between cancer development and cancer-associated pain in oral squamous cell carcinoma (Review).
- Authors
YU ZHANG; CHENGZHONG LIN; XU WANG; TONG JI
- Abstract
Nerves have been widely demonstrated to exert major effects in tumor-associated microenvironments. Due to the characteristic innervation of the oral cavity and the fact that cancer-associated pain is a distinct feature of oral squamous cell carcinoma (OSCC), the sensory nerves may dominate in the OSCC-nerve microenvironment. As the most abundant neuropeptide in the trigeminal ganglion, the calcitonin gene-related peptide (CGRP) exerts a dual effect on cancer development and cancer-associated pain in various types of cancer. The present review explored the potential molecular mechanisms of the roles of CGRP in cancer development and cancer-associated pain, suggesting that CGRP may be a promising therapeutic target for OSCC.
- Subjects
CALCITONIN gene-related peptide; SQUAMOUS cell carcinoma; MOUTH; CANCER; PAIN
- Publication
Oncology Letters, 2020, Vol 20, Issue 5, p1
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.12116